Neuroprotective effect of minocycline on PTZ-induced epileptiform activity and alterations of the shape of action potentials in snail neurons assessed by using intracellular recordings
نویسندگان
چکیده
Introduction: Epilepsy is a neurological disorder that affects 1-2% of the world population and about 30% of patients are resistant to antiepileptic drug therapy. Therefore, new treatment alternatives are needed. In the present study, the possible neuroprotective effect of minocycline against epileptiform activity induced by pentylenetetrazole
منابع مشابه
Neuroprotective effect of minocycline on PTZ-induced epileptiform activity and alterations of the shape of action potentials in snail neurons assessed by using intracellular recordings
Introduction: Epilepsy is a neurological disorder that affects 1-2% of the world population and about 30% of patients are resistant to antiepileptic drug therapy. Therefore, new treatment alternatives are needed. In the present study, the possible neuroprotective effect of minocycline against epileptiform activity induced by pentylenetetrazole (PTZ) was assessed. Methods: Conventional intra...
متن کاملElectrophysiological investigation of the cellular effect of anethole, the chief constitute of anise, on F1 neuronal excitability in garden snail
Introduction: Anethole is the main constituent of Pimpinella anisum L. (anise), a herbaceous annual plant which has several therapeutic effects. In the folk medicine, anise is employed as an antiepileptic drug. Specifically, this study was focused on the cellular effect of anethole, an aromatic compound in essential oils from anise and camphor. Anethole has various physiological effects on t...
متن کاملEffects of Dorema ammoniacum Gum on Neuronal Epileptiform Activity-Induced by Pentylenetetrazole
Epilepsy is a chronic neurological disease which disrupts the neuronal electrical activity. One-third of patients are resistant to treatment with available antiepileptic agents. The use of herbal medicine for treating several diseases including epilepsy is on the rise. Therefore, further investigation is required to verify the safety and effectiveness of Phytomedicine in treating diseases. The ...
متن کاملEffects of Dorema ammoniacum Gum on Neuronal Epileptiform Activity-Induced by Pentylenetetrazole
Epilepsy is a chronic neurological disease which disrupts the neuronal electrical activity. One-third of patients are resistant to treatment with available antiepileptic agents. The use of herbal medicine for treating several diseases including epilepsy is on the rise. Therefore, further investigation is required to verify the safety and effectiveness of Phytomedicine in treating diseases. The ...
متن کاملMinocycline Mitigation of Tremor Syndrome and Defect of Cognitive and Balance Induced by Harmaline
Introduction: Minocycline has anti-inflammatory, anti-apoptotic, and anti-oxidant effects. Preclinical data suggest that minocycline could be beneficial for treating common neurological disorders, including Parkinson disease and multiple sclerosis. Methods: In this study, the effects of minocycline on harmaline-induced motor and cognitive impairments were studied in male Wistar rats. The rats ...
متن کامل